Fariba Sadeghi; Seyed Mohammad Bagher Fazljou; Bita Sepehri; Laleh Khodaie; Hassan Monirifar
Volume 22, Issue 6 , 2020
Abstract
Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conven- tional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders.
Objectives: ...
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Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conven- tional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders.
Objectives: This study aimed to assess the effects of Pistacia lentiscus (mastic) and Coriander Triphala on reflux symptoms compared to omeprazole in a double-blinded randomized clinical trial.
Methods: In a double-blinded, multicenter, randomized clinical trial, we assessed the effects of Pistacia lentiscus L., Coriander Triphala, and omeprazole on the symptoms of GERD in Tabriz, Iran, in 2018 - 2019. Thus, 105 patients with GERD symptoms were assigned randomly to three groups as group A (Pistacia lentiscus L., 1000 mg/TDS), group B (Coriander Triphala, 1000 mg/TDS), and group C (omeprazole, 20 mg/day plus five placebo capsules per day). The assessments were done at the beginning and the end of the study using FSSG, VAS, RS, and GERD-HRQL questionnaires.
Results: In the beginning, no significant differences were observed between the groups in the background characteristics. There was no statistically significant difference between Pistacialentiscus, Coriander Triphala, and omeprazole in the improvement of FSSG, VAS, GERD-HRQL, and reflux scores. In all groups, the FFSG, VAS, reflux, and GERD-HRQL scores significantly decreased and improved after four weeks of intervention compared to the respective baselines. The FSSG score improvements after four weeks of intervention were 73.68%, 83.33%, and 68.62%, in groups A, B, and C, respectively. The VAS score improvements were 66.66%, 75.00%, and 62.50% in groups A, B, and C, respectively. Improvements in GERD-HRQL were 90.00%, 91.28%, and 82.00%, in groups A, B, and C, respectively. Reflux improvements were 66.66%, 80.00%, and 66.66% in groups A, B, and C, respectively.
Conclusions: The results showed that Pistacia lentiscus and Coriander Triphala are as effective as omeprazole in the treatment of GERD.
Mojgan Mirghafourvand; Sakineh Mohammad Alizadeh Charandabi; Sevil Hakimi; Laleh Khodaie; Mina Galeshi
Volume 19, Issue 2 , February 2017, , Pages 1-8
Abstract
Background: Mothers are vulnerable to mental disorders, such as depression and anxiety, in the 6-week postpartum period after delivery.Objectives: This study was performed to determine the potential effect of orange peel essential oil on postpartum depression and anxiety.Patients and Methods: This double-blind ...
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Background: Mothers are vulnerable to mental disorders, such as depression and anxiety, in the 6-week postpartum period after delivery.Objectives: This study was performed to determine the potential effect of orange peel essential oil on postpartum depression and anxiety.Patients and Methods: This double-blind randomized controlled clinical trial consisted of 96 postpartum women. Qualified samples were assigned to intervention and control groups using randomized blocking. The intervention group drank a glass of water containing 10 drops of orange peel essential oil, and the control group drank a glass a water containing 10 drops of placebo, 3 times a day, after each meal for 8 weeks. The subjects completed depression and anxiety questionnaires before and after the intervention. A general linear model was used to analyze the data.Results: There was no statistically significant difference between the groups in terms of sociodemographic characteristics and depression and anxiety scores before and after the intervention (P > 0.05). At the end of the 8th week, the mean depression score (standard deviation [SD]) was 6.7 (4.7) in the orange peel essential oil group and 6.7 (4.9) in the placebo group (P = 0.956). The mean state anxiety score was 47.6 (3.8) in the orange peel essential oil group and 48.4 (4.1) in the placebo group (P = 0.197). The mean trait anxiety score was 45.6 (3.5) in the orange peel essential oil group and 45.9 (3.8) in the placebo group (P = 0.726).Conclusions: Orange peel essential oil did not reduce postpartum depression and anxiety.
